Lecture 'Origin of Human Lung Macrophages in Steady State and Inflammation'

For whom
Alumni , Business , Employees , Students
02-12-2022 from 11:30 to 12:30
UGent-VIB-onderzoeksgebouw, Technologiepark 71, 9052 Zwijnaarde
VIB-UGent Center for Inflammation Research

Human lung macrophages are essential for host defense but are poorly understood. In this talk, a humanized mouse model helps to find the truth.

Prof Tim Willinger (Karolinska Institutet, Center for Infectious Medicine, Sweden) is our guest.

"I will discuss our recent research to dissect the cellular origin and ontogeny of human lung macrophages. Macrophages are the most abundant type of immune cell in the airways and are essential for tissue homeostasis and host defense in the lung. Lung macrophages have been extensively studied in mice, but their developmental pathways in humans have remained poorly understood. We created a unique humanized mouse model (MISTRG) to investigate the origin and ontogeny of human lung macrophages in vivo. With the help of this in-vivo model, we identified both the fetal and the adult progenitor of human lung macrophages. Using intravascular cell labeling and single-cell RNA-sequencing, we also defined how blood monocytes give rise to distinct types of lung macrophages. Finally, we determined the impact of cell origin on the identity and function of human lung macrophages."