Lise Vandevivere

Lise Vandevivere

Laboratory of Pharmaceutical TechnologyLIse Vandevivere
Ottergemsesteenweg 460
B-9000 Gent(Belgium)
Tel. : +32-9-264.81.18
E-mail :


Pharm. Lise Vandevivere graduated as pharmacist in 2016 from Ku Leuven where she obtained his master in Pharmaceutical Care in 2016. For her Master’s thesis, she evaluated the usage of benzodiazepines in a psychiatric institution. In 2016, she started her PhD research on The development of formulations of highly dosed and poorly wettable API’s through twin screw granulation.

Summary of Research Project(s)

Nowadays continuous manufacturing is quickly gaining momentum in the pharmaceutical sector. Twin screw granulation is a continuous process that can be implemented into a fully continuous from-powder-to-tablet line. This implies important economic advantages and improved product quality. While most of previous studies focused on the influence of process parameters on granule and tablet quality, only a limited number of studies concentrates on formulation development. The aim of the current study is to develop formulations including highly dosed and poorly wettable APIs through twin screw granulation. This topic is considered as challenging because of the short residence time via twin screw granulation (typically 5 – 20s), which implies limited interaction between powder bed and the granulation liquid. Furthermore, to granulate such APIs high amounts of aqueous granulation liquids are required which in turn results in excessively long drying times to be applied to dry the granules. This can limit the suitability of the six-segmented fluid bed dryer of the ConsiGmaTM-system as the maximal applicable drying time is approximately six times the filling time of one cel of the fluid bed dryer. Therefore different binders and surfactants (in different concentrations) will be evaluated on the quality of granules and tablets with a high drug load of poorly wettable APIs produced via twin screw granulation.